Publications (since July 2013)

Book chapters

A.M. Mendes, A. Scholzen, A.K. Mueller, S.M. Khan, R.W. Sauerwein, M. Prudêncio (2017) “Whole Organism Pre-Erythrocytic Vaccines”, In: Rodriguez, A. and Mota M.M. (Eds) Malaria: immune response to infection and vaccination, Springer International Publishing, Cham, Switzerland

Scientific articles

62. M. Prudêncio (2021) “Portugal’s prominence in malaria research”, EMBO Reports, e51692

61. I Bártolo, B.S. Santos, D. Fontinha, M. Machado, D. Francisco, B. Sepodes, J. Rocha, H. Mota-Filipe, R. Pinto, M.E. Figueira, H. Barroso, T. Nascimento, A.P.A. de Matos, A.J.S. Alves, N.G. Alves, C.J.V. Simões, M. Prudêncio, T.M.V.D. Pinho e Melo, N. Taveira (2021) “Spiro-β-lactam BSS-730A displays potent activity against HIV and Plasmodium”, ACS Infectious Diseases, in press

60. M. Fonte, N. Tassi, D. Fontinha, I. Bouzón-Arnáiz, R. Ferraz, M.J. Araújo, X. Fernàndez-Busquets, M. Prudêncio, P. Gomes, C. Teixeira (2020) “4,9-diaminoacridines and 4-aminoacridines as antiplasmodial hits”. ChemMedChem, in press

59.  Y. Miyazaki, C.Y. Marin, T. Imai, A.M. Mendes, R. vd Laak, A. Sturm, F.J. Geurten, S. Miyazaki, S.C. Chevalley-Maurel, J. Ramesar, S.K. Kolli, J. Kroeze, R. van Schuijlenburg, A.M. Salman, B.K. Wilder, A. Reyes-Sandoval, K. Dechering, M. Prudêncio, C.J. Janse, S.M. Khan, B. Franke-Fayard (2020) “Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing P. vivax circumsporozoite protein for malaria vaccine development”, Frontiers in Cellular and Infection Microbiology, 10, 591046

58. P. Meireles, D. Brás, D. Fontinha, A.F. Chora, K. Serre, A.M. Mendes*, M. Prudêncio* (2020) “Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation”, iScience, 23, 101781 (*Corresponding authors).  Recommended by Faculty Opinions

57.  M. Marinović, I. Perković, D. Fontinha, M. Prudêncio, J. Held, L. Pessanha de Carvalho, T. Tandarić, R. Vianello, B. Zorc, Z. Rajić (2020) “Novel Harmicines with Improved Potency against Plasmodium”, Molecules, 25, 4376

56. M. Prudêncio (2020) "In fairness to mosquitoes", Trends in Parasitology, 36, 876-877

55.  S.A. Milheiro, J. Gonçalves, R.M.R.M. Lopes, M. Madureira, L. Lobo, A. Lopes, F. Nogueira, D. Fontinha, M. Prudêncio, M.F.M. Piedade, S.N. Pinto, P.R. Florindo, R. Moreira (2020) “Half- sandwich cyclopentadienylruthenium(II) complexes: a new antimalarial chemotype”, Inorganic Chemistry, in press

54.  D. Fontinha, I. Moules, M. Prudêncio (2020) "Repurposing drugs to fight hepatic malaria parasites", Molecules, 25, 3409

53. M. Prudêncio, J.C. Costa (2020) "Research funding after COVID-19", Nature Microbiol., 5, 986

52. D. Fontinha, S.A. Sousa, T.S. Morais, M. Prudêncio, J.H. Leitão, Y.L. Gal, D. Lorcy, R.A.L. Silva, M.F.G. Velho, D. Belo, M. Almeida, J.F. Guerreiro, T. Pinheiro, F. Marques (2020) "Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents", Metallomics12, 974-987

51.  I.J. Reuling *, A.M. Mendes*, G.M. de Jong GM*, A. Fabra-García*, H. Nunes-Cabaço*, G.J. van Gemert, W. Graumans, L.E. Coffeng, S.J. de Vlas, A.S.P. Yang, C.K. Lee, Y. Wu, A.J. Birkett, C.F. Ockenhouse, R. Koelewijn, J.J. van Hellemond, P.J.J. van Genderen**, R.W. Sauerwein**, M. Prudêncio** (2020) “Safety and efficacy of a genetically modified rodent malaria parasite against Plasmodium falciparum malaria: an open-label randomized phase 1/2a trial”, Science Transl. Med., 12, eaay2578. *Equally contributing authors; **Corresponding authors. Issue cover.

50. L. Singh, D. Fontinha, D. Francisco, A.M. Mendes, M. Prudêncio, K. Singh (2020) “Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites”, J. Med. Chem., 63, 1750-1762

49. R. Azevedo, A.M. Mendes, M. Prudêncio (2020) "The impact of antiretroviral therapy on malaria parasite transmission”, Frontiers in Microbiology-Infectious Diseases, 10, 3048

48. L. Balasubramanian, V. Zuzarte-Luís, T. Syed, D. Mullick, S. Deb, H. Prasad, J. Meissner, A.S. Almeida, T. Furstenhaupt, K. Siddiqi, M. Prudêncio, C.M. Rodrigues, M.M. Mota, V. Sundaramurthy (2020) "Association of Plasmodium berghei with the apical domain of hepatocytes is necessary for the parasite's liver stage development", Frontiers in Cellular Infection Microbiology, 9, 451

47.  I. Perković, S. Raić-Malić, D. Fontinha, M. Prudêncio, L.P. Carvalho, J. Held, T. Tandarić, R. Vianello, B. Zorc, Zrinka Rajić (2020) "Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits", Eur. J. Med. Chem., 187, 111927

46. S.A. Sousa, J.H. Leitão, R.A.L. Silva, D. Belo, I.C. Santos, J.F. Guerreiro, M. Martins, D. FontinhaM. Prudêncio, M. Almeida, D. Lorcy, F. Marques (2020) "On the Path to Gold: Monoanionic Au Bisdithiolate Complexes with 1 Antimicrobial and Antitumor Activities", Journal of Inorganic Biochemistry, 202, 110904

45. A.J.S. Alves, N.G. Alves, C.C. Caratão, Esteves M., D. Fontinha, I. Bártolo, M.I.L. Soares, S.M.M. Lopes, M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2019) "Spiro-Lactams as Novel Antimicrobial Agents", Curr. Top. Med. Chem., 20, 140-152

44. M. Sanches-Vaz, A. Temporão, R. Luis, H. Nunes-Cabaço, A.M. Mendes, S. Goellner, T. Carvalho, L.M. Figueiredo*, M. Prudêncio* (2019) "Trypanosoma brucei infection protects mice against malaria", PLoS Pathogens, 15, e1008145 (* Corresponding authors)

43. R. Azevedo, A.M. Mendes, M.Prudêncio (2019) "Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins", Parasites & Vectors, 12, 594

42. F. Arez, S. Rebelo, D. Fontinha, D. Simão, T.R. Martins, M. Machado, C. Fischli, C. Oeuvray, L. Badolo, M. J. T. Carrondo, M. Rottmann, T. Spangenberg, C. Brito, B. Greco*, M. Prudêncio*, P.M. Alves* (2019) “Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection”, ACS Infect. Dis., 5, 1831-1842 (* Corresponding authors)

41.  K. Pavić, B. Rubinić, Z. Rajić, D. Fontinha, M. Prudêncio, L. Uzelac, M. Kralj, J. Held, B. Zorc (2019) “Primaquine homodimers as potential antiplasmodial and anticancer agents”, Bioorganic & Medicinal Chemistry Letters, 29, 126614

40. K. Wolanin, D. Fontinha, M. Sanches‐Vaz, B. Nyboer, Kirsten Heiss, A.-K. Mueller, M. Prudêncio (2019) “A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle”, Cell. Microbiol., e13088

39. M. Beus, D. Fontinha, J. Held, Z. Rajić, L. Uzelac, M. Kralj, M. Prudêncio, B. Zorc (2019) "Primaquine and chloroquine fumardiamides as promising antiplasmodial agents”, Molecules, 24, 2812

38. M. Beus*, D. Fontinha*, J. Held, Z. Rajić, M. Prudêncio, B. Zorc (2019) "Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides", Acta Pharmaceutica, 69, 233-248 (* Equally contributing authors)

37. L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, Paula Gomes (2019) “Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites”, MedChemComm, 10, 221-226

36. G. Mayoka, M. Njoroge, J. Okombo, L. Gibhard, M. Sanches-Vaz, D. Fontinha, L.M. Birkholtz, J. Reader, M. van der Watt, T.L. Coetzer, S. Lauterbach, A. Churchyard, B. Bezuidenhout, T.J. Egan, C.L. Yeates, S. Wittlin, M. Prudêncio, K. Chibale (2019) “Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria”, J. Med. Chem., 62, 1022-1035

35. M. Kumar, J. Okombo, D. Mambwe, D. Taylor, N. Lawrence, J. Reader, M.V. Watt, D. Fontinha, M. Sanches-Vaz, B. Bezuidenhout, S. Lauterbach, D. Liebenberg, L.M. Birkholtz, T.L. Coetzer, M. Prudêncio, T.J. Egan, S. Wittlin, K. Chibale (2019) “Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action”, ACS Infect. Dis., 5, 303-315

34. A.M. Mendes, I.J. Reuling, C.M. Andrade, T.D. Otto, M. Machado, F. Teixeira, J. Pissarra, N. Gonçalves-Rosa, D. Bonaparte, J. Sinfrónio, M. Sanders, C.J. Janse, S.M. Khan, C.I. Newbold, M. Berriman, C. Lee, Y. Wu, C.F. Ockenhouse, R.W. Sauerwein, M. Prudêncio (2018) "Pre-Clinical Evaluation of a P. berghei-Based Whole-Sporozoite Malaria Vaccine Candidate", NPJ Vaccines, 3, 54

33. M. Beus, Z.R. Džolić, D. Maysinger, Z. Mlinarić, M. Antunović, I. Marijanović, D. Fontinha, M. Prudêncio, J. Held, S. Olgen, B. Zorc (2018) "SAHAquines, novel hybrids based on SAHA and primaquine motifs, as potential cytostatic and antiplasmodial agents", ChemistryOpen, 7, 624-638

32. A.M. Mendes, M. Machado, N. Gonçalves-Rosa, I.J. Reuling, L. Foquet, C. Marques, A.M. Salman, A.S.P. Yang, K.A. Moser, A. Dwivedi, C.C. Hermsen, B. Jiménez-Díaz, S. Viera, J.M. Santos, I. Albuquerque, S.N. Bhatia, J. Bial, I. Angulo-Barturen, J.C. Silva, G. Leroux-Roels, C.J. Janse, S.M. Khan, M.M. Mota, R.W. Sauerwein, M. Prudêncio (2018) "A Plasmodium berghei Sporozoite-Based Vaccination Platform Against Human Malaria", NPJ Vaccines, 3, 33

31. R. Capela, J. Magalhães, D. Miranda, M. Machado, M. Sanches-Vaz, I.S. Albuquerque, M. Sharma, J. Gut, P.J. Rosenthal, R. Frade, M.J. Perry, R. Moreira, M. Prudêncio*, F. Lopes* (2018) "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability", Eur. J. Med. Chem., 149, 69-78. *- Corresponding authors

30. M. Šafratová, A. Hošťálková, D. Hulcová, K. Breiterová, V. Hrabcová, M. Machado, D. Fontinha, M. Prudêncio, J. Kuneš, J. Chlebek, D. Jun, M. Hrabinová, L. Nováková, R. Havelek, M. Seifrtová, L. Opletal, L. Cahlíková (2018) "Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity", Arch. Pharmacal Res., 41, 208-218

29. K. Pavic, I. Perkovic, S. Popisilova, M. Machado, D. Fontinha, M. Prudêncio, J. Jampilek, A. Coffey, L. Endersen, H. Rimac, B. Zorc (2017) "Primaquine hybrids as promising antimycobacterial and antimalarial agents", Eur. J. Med. Chem., 143, 769-779

28. T.S. Macedo, W. Villarreal, C.C. Couto, D.R.M. Moreira, M. Navarro, M. Machado, M. Prudêncio, A.A. Batista, M.B.P. Soares (2017) "Platinum(II)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function", Metallomics, 9, 1548-1561

27. M. Machado, M. Sanches-Vaz, J.P. Cruz, A.M. Mendes, M. Prudêncio (2017) "Inhibition of Plasmodium hepatic infection by antiretroviral compounds", Front. Cell. Infect. Microbiol., 7, doi: 10.3389/fcimb.2017.00329

26. P. Meireles, A.M. Mendes, R.I. Aroeira, B.C. Mounce, M. Vignuzzi, H.M. Staines, M. Prudêncio (2017) "Uptake and metabolism of arginine impact Plasmodium development in the liver", Sci. Rep., 7, 4072

25. R. Azevedo§, M. Markovic§, M. Machado, B. Franke-Fayard, A.M. Mendes*, M. Prudêncio* (2017) "A bioluminescence method for in vitro screening of Plasmodium transmission-blocking compounds", Antimicrob. Agents Chemother., 61, 202699-16. §- Equally contributing authors; *- Corresponding authors

24. K. Singh, J. Okombo, C. Brunschwig, F. Ndubi, L. Barnard, C. Wilkinson, P.M. Njogu, M. Njoroge, L. Laing, M. Machado, M. Prudêncio, J. Reader, M. Botha, S. Nondaba, L.M. Birkholtz, S. Lauterbach, A. Churchyard, T.L. Coetzer, J.N. Burrows, C. Yeates, P. Denti, L. Wiesner, T.J. Egan, S. Wittlin, K. Chibale (2017) "Antimalarial pyrido[1,2-a]benzimidazoles: Lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics and in vivo oral efficacy in a mouse model", J. Med. Chem., 60, 1432-1448

23. C.S. Cunha§, B. Nyboer§, K. Heiss, M. Sanches-Vaz, D. Fontinha, E. Wiedtke, D. Grimm, J.M. Przyborski, M.M. Mota, M. Prudêncio*, A.K. Mueller* (2017) "P. berghei EXP-1 Interacts with Host Apolipoprotein H during Plasmodium Liver Stage Development", Proc. Natl. Acad. Sci. USA, 114, E1138-E1147. §- Equally contributing authors; *- Corresponding authors

22. A.M. Mendes, I.S. Albuquerque, M. Machado, J. Pissarra, P. Meireles, M. Prudêncio (2017) "Inhibition of Plasmodium liver infection by ivermectin", Antimicrob. Agents Chemother., 61, e02005-16

21. M.A.S. Cavadas, M.P. Monopoli, C.S. Cunha, M. Prudêncio, E. Pereira, I. Lynch, K.A. Dawson, R. Franco (2016) "Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates", Particle & Particle Systems Characterization, 33, 906-915

20. Carrasco M.P.*, Machado M., Gonçalves L., Sharma M., Gut J., Lukens A.K., Wirth D.F., André V., Duarte M.T., Guedes R.C., Dos Santos D., Rosenthal P.J., Mazitschek R., Prudêncio M.*, Moreira R. (2016) "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites", ChemMedChem, 11, 2194-2204  (* Corresponding authors)

19. P. Meireles, J. Sales-Dias, C.M. Andrade, J. Mello-Vieira, L. Mancio-Silva, J.P. Simas, H.M. Staines, M. Prudêncio (2016) "GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection", Cell. Microbiol., doi:10.1111/cmi.12646

18. R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. PrudêncioB., S. Parapini, S. D’Alessandro, C. Teixeira, A. Gomes, C. Prudêncio, P. Gomes (2016) "Primaquine-based ionic liquids as a novel class of antimalarial hits", RSC Advances, 6, 56134-56138

17. T.S. Macedo, L.C. Vegas, M. Paixão, M. Navarro, B.C. Barreto, P.C.M..Oliveira, S.G. Macambira, M. Machado, M. Prudêncio, S. D’Alessandro, N. Basilico, D.R.M. Moreira, A.A. Batista, M.B.P. Soares (2016) "Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents", Parasitology, 143, 1543-1556

16. C.J.A. Ribeiro, M. Espadinha, M. Machado, J. Gut, L.M. Gonçalves, P.J. Rosenthal, M. Prudêncio, R. Moreira, M.M.M. Santos (2016) "Novel squaramides with in vitro liver stage antiplasmodial activity", Bioorg. Med. Chem., 24, 1786-1792

15. N. Terzić, J. Konstantinović, M. Tot, J. Burojević, O. Djurković-Djaković, J. Srbljanović, T. Štajner, T. Verbić, M. Zlatović, M. Machado, I.S. Albuquerque, M. Prudêncio*, R.J. Sciotti, S. Pecic, S. D’Alessandro, D. Taramelli, B.A. Šolaja* (2016) "Re-investigating old pharmacophores: Are 4-aminoquinolines and tetraoxanes potential two-stage antimalarials?", J. Med. Chem., 59, 264-281 (* Corresponding authors)

14. I. Gomes, A. Reis, E. Pereira, E. Fortunato, M. Prudêncio, R. Franco (2015) "Nanoimunoensaios para diagnóstico de malária", An. Inst. Hig. Med. Trop., 14, 21-30

13. N.A.L. Pereira, Â. Monteiro, M. Machado, J. Gut, E. Molins, M.J. Perry, J. Dourado, R. Moreira, P.J. Rosenthal, M. Prudêncio*, and M.M.M. Santos* (2015), "Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites". ChemMedChem, 10, 2080-2089 (* Corresponding authors)

12. A. Gomes, M. Machado, L. Lobo, F. Nogueira, M. Prudêncio, C. Teixeira, P. Gomes (2015) "N-cinnamoylation of antimalarial classics: Effects of using acyl groups other than cinnamoyl toward dual-stage antimalarials", ChemMedChem, 10, 1344-134

11. H. Kaur, M. Machado, C. de Kock, P. Smith, K Chibale, M Prudêncio, K. Singh (2015) "Primaquineepyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity", European Journal of Medicinal Chemistry, 101, 266-273

10. M.D. Lewis, J. Behrends, C.S. Cunha, A.M. Mendes, F. Lasitschka, K. Heiss, T.W.A. Kooij, M.Prudêncio, F.Frischknecht and A.-K. Mueller (2015), "Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression", Journal of Immunology, 194, 4860-4870

9. C.A.B. Rodrigues, R.F.M. Frade, I.S. Albuquerque, M.J. Perry, J. Gut, M. Machado, P.J. Rosenthal, M. Prudêncio, C.A.M. Afonso, R. Moreira (2015), "Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids", ChemMedChem, 10, 883-890

8. P. Liehl*, P. Meireles*, I.S. Albuquerque, M. Pinkevych, F. Baptista, M.M. Mota, M.P. Davenport, M. Prudêncio (2015), "Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections", Infection and Immunity, 83, 1172-1180. (* Equally contributing authors)

7. C. Ramalhete, F.P. da Cruz, I.J. Sousa, S. Mulhovo, M.X. Fernandes, M. Prudêncio, M.-J.U. Ferreira (2014), "Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite", Bioorganic & Medicinal Chemistry, 22, 3887-3890

6. R. Oliveira, R.C. Guedes, P. Meireles, I.S. Albuquerque, L.M. Gonçalves, E. Pires, M.R. Bronze, J. Gut, P.J. Rosenthal, M. Prudêncio, R. Moreira, P.M. O’Neill, F. Lopes (2014), "Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials", J. Med. Chem., 57, 4916-4923

5. D. Miranda, R. Capela, I.S. Albuquerque, P. Meireles, I. Paiva, F. Nogueira, R. Amewu, J. Gut, P.J. Rosenthal, R. Oliveira, M.M. Mota, R. Moreira, F. Marti, M. Prudêncio, P.M. O’Neill, F. Lopes (2014) "Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities", ACS Medicinal Chemistry Letters, 5, 108-112

4. A. Gomes, B. Pérez, I. Albuquerque, M. Machado, M. Prudêncio, F. Nogueira, C. Teixeira, P. Gomes (2014) "N-cinnamoylation of antimalarial classics: new quinacrine analogues with reduced toxicity and dual-stage activity", ChemMedChem, 9, 305-310

3. P. Liehl, V. Zuzarte-Luís, J. Chan, T. Zillinger, F. Baptista, D.l Carapau, M. Konert, K. Hanson, C. Carret, C. Lassnig, M. Müller, U. Kalinke, M. Saeed, A.F. Chora, D.T. Golenbock, B. Strobl, M. Prudêncio, L.P. Coelho, S.H. Kappe, G. Superti-Furga, A. Pichlmair, A.M. Vigário, C.M. Rice, K.A. Fitzgerald, W. Barchet, M.M. Mota (2014) "Host cell sensors for Plasmodium activate innate immunity against liver stage infection", Nature Medicine, 20, 47-53

2.  A.S. Ressurreição, D. Gonçalves, A.R. Sitoe, I.S. Albuquerque, J. Gut, A. Góis, L.M. Gonçalves, M.R. Bronze, T. Hanscheid, G.A. Biagini, P.J. Rosenthal, M. Prudêncio, P. O'Neill, M.M. Mota, F. Lopes, R. Moreira (2013) "Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: towards increased potency and metabolic stability", J. Med. Chem, 56, 7679-7960

1. T. Rodrigues, A.S. Ressurreição, F.P. da Cruz, I.S. Albuquerque, J. Gut, M. Carrasco, D. Gonçalves, M.M. Mota, P.J. Rosenthal, R. Moreira, M. Prudêncio, F. Lopes (2013) "Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds", Eur. J. Med. Chem., 69, 872-880