Publications (since July 2013)


Book chapters

A.M. Mendes, A. Scholzen, A.K. Mueller, S.M. Khan, R.W. Sauerwein, M. Prudêncio (2017) “Whole Organism Pre-Erythrocytic Vaccines”, In: Rodriguez, A. and Mota M.M. (Eds) Malaria: immune response to infection and vaccination, Springer International Publishing, Cham, Switzerland


Scientific articles

87. D. Moita, T.G. Maia, M. Duarte, C.M. Andrade, I.S. Albuquerque, A. Dwivedi, J.C. Silva, L. González-Céron, C.J. Janse, A.M. Mendes, M. Prudêncio (2022) “A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria”, NPJ Vaccines, 7, 163, 1-9


86. B. Franke-Fayard, C. Marin-Mogollon, F.J.A. Geurten, S. Chevalley-Maurel, J. Ramesar, H. Kroeze, E Baalbergen, E. Wessels, L. Baron, V. Soulard, T. Martinson, M. Aleshnick, A.T.G. Huijs, A.K. Subudhi, Y. Miyazaki, A.S. Othman, S. K. Kolli, O.A.C. Lamers, M. Roques, R.R. Stanway, S.C. Murphy, L. Foquet, D. Moita, A.M. Mendes, M. Prudêncio, K.J. Dechering, V.T. Heussler, A. Pain., B.K. Wilder, M. Roestenberg, C.J. Janse (2022) “Creation and preclinical 1 evaluation of genetically attenuated malaria parasites arresting growth late in the liver”, NPJ Vaccines, 7, 139, 1-17


85. A.J. Alves, N.G. Alves, I. Bártolo, D. Fontinha, S. Caetano, M. Prudêncio, N.Taveira, T.M. Pinho e Melo (2022) “Unveiling a family of spiro‐beta‐lactams with anti-HIV and anti-plasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates”, Front. Chem., 10, 1017250


84. H. Nunes-Cabaço, D. Moita, M. Prudêncio (2022) "Five decades of clinical assessment of whole-sporozoite malaria vaccines", Front. Immunol., 13, 977472


83.  I. Bouzón-Arnáiz; Y. Avalos-Padilla; A. Biosca; O. Caño-Prades; L. Román-Álamo; J. Valle; D. Andreu; D. Moita; M. Prudêncio; E.M. Arce; D. Muñoz-Torrero; X. Fernàndez-Busquets (2022) “The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures", BMC Biology, 20, 197, 1-27


82. Y. Le Gal, A. Filatre-Furcate, D. Lorcy, O. Jeannin, T. Roisnel, V. Dorcet, D. FontinhaD. FranciscoM. Prudêncio, M. Martins, C. Soeiro, S.A. Sousa, J.H. Leitão, T.S. Morais, I. Bártolo, N. Taveira, J.F. Guerreiro, F. Marques (2022) “Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes”, Int. J. Mol. Sci., 23, 7146


81.  C.S. Pereira, H.C. Quadros, S.Y. Aboagye, D. Fontinha, S. D’Alessandro, M.E. Byrne, M. Gendrot, I. Fonta, J. Mosnier, D. Rodrigo, M. Moreira, N. Basilico, D.L. Williams, M. Prudêncio, B. Pradines, M. Navarro (2022) "Hybrid of amodiaquine and primaquine linked by gold(I) is a multistage antimalarial agent by targeting heme detoxification and thiol redox homeostasis", Pharmaceutics, 14, 1251


80. A. Khandelwal, F. Arez, P.M. Alves, L. Badolo, C. Brito, C. Fischli, D. Fontinha, C. Oeuvray, M. Prudêncio, M. Rottmann, J. Wilkins, Ö. Yalkinoglu, W.M. Bagchus, T. Spangenberg (2022) “Translation of liver stage activity of M5717, a Plasmodium Elongation Factor 2 inhibitor - from bench to bedside”, Malaria J., 21, 151


79. H. Nunes-Cabaço, D. Moita, C. Rôla, A.M. Mendes, M. Prudêncio (2022) “Impact of dietary protein restriction on the immunogenicity and efficacy of whole-sporozoite malaria vaccination”, Front. Immunol., 13, 869757


78. E.A. Lopes, R. Mestre, D. Fontinha, J. Legac, J.V. Pei, M. Sanches-Vaz, M. Mori, A.M. Lehane, P.J. Rosenthal, M. Prudêncio, M.M.M. Santos (2022) “Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity”, Eur. J. Med. Chem.236, 114324


77. D. Jublot, P. Cavaillès, S. Kamche, D. Francisco, D. Fontinha, M. Prudêncio, J.-F. Guichou, G. Labesse, D. Sereno, C. Loeuillet (2022) "A Histone deacetylase (HDAC) inhibitor with pleiotropic in vitro anti-Toxoplasma and Plasmodial activities controls acute and chronic toxoplasma infection in mice", Int. J. Mol. Sci., 23, 3254


76.  D. Fontinha*, F. Arez*, I.R. Gal, G. Nogueira, D. Moita, T.H.H. Baeurle, C. Brito, T. Spangenberg**, P.M. Alves**, M. Prudêncio** (2022) "Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models", ACS Inf. Dis., 8, 721-727*Equally contributing authors; **Corresponding authors.


75.  A.F. Chora, M.M. Mota, M. Prudêncio (2022) "The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle", Int. J. Parasitol., 52, 711-715


74.  S. Portugal, A. Rodriguez, M. Prudêncio (2022) “Maria M. Mota: Bringing Plasmodium Liver Infection to the Centre Stage of Malaria Research”, Front. Cell. Infect. Microbiol., 12, 851484


73. L. Singh, D. Fontinha, D. Francisco, M. Prudêncio, K. Singh (2022) “Synthesis and Antiplasmodial Activity of Regioisomers and Epimers of Second-Generation Dual Acting Ivermectin Hybrids“, Sci. Rep., 12,564


72. C. Upadhyay, N. Sharma, S. Kumar, P.P. Sharma, D. Fontinha, B.S. Chhikara, B. Mukherjee, D. Kumar, M. Prudêncio, A.P. Singh, Poonam (2022) “Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum", New. J. Chem., 46, 250


71. A.T. Silva, I.S. Oliveira, J. Gomes, L. Aguiar, D. Fontinha, D. Duarte, F. Nogueira, M. Prudêncio, E.F. Marques, C. Teixeira, R. Ferraz, P. Gomes (2021) “Drug-derived surface-active ionic liquids: a cost-effective way to expressively increase blood-stage antimalarial activity of primaquine“, ChemMedChem, e202100650


70.  H.C. Quadros, A. Çapcı, L. Herrmann, S. D’Alessandro, D. Fontinha, R. Azevedo, W. Villarreal, N. Basilico, M. Prudêncio, S.B. Tsogoeva, D.R.M. Moreira (2021) “Studies of Potency and Efficacy of an Optimized Dihydroartemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle”, Pharmaceuticals, 14, 1129


69. T. Araki*, J. Lin*, M. Prudêncio*, D.A. Cunningham*, T. Annoura* (2021), “Editorial Malaria Targeting Toolkit: Host-Parasite Interactions” Front. Cell. Infect. Microbiol., 11, 79549 *Corresponding authors


68.  A. Temporão*, M. Sanches-Vaz*, R. Luís, H. Nunes-Cabaço, T.K. Smith, M. Prudêncio**, L. Figueiredo** (2021) "Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection", PLoS Negl. Trop. Dis., October 29. * Equally contributing authors; **Corresponding authors. Recommended by Faculty Opinions.


67. M. Marinović, G. Poje, I. Perković, D. Fontinha, M. Prudêncio, J. Held, L.P. Carvalho, T. Tandarić, R. Vianello, Z. Rajić (2021), “Further investigation of harmicines as novel antiplasmodial agents: Synthesis,structure-activity relationship and insight into the mechanism of action”, Eur. J. Med. Chem., 224, 113687


66.  C.S. Pereira, H.C. Quadros, D.R.M. Moreira, W. Castro, Silva R.I.S.D.S., M.B.P. Soares, D. FontinhaM. Prudêncio, V. Schmitz, H.F. Santos, M. Gendrot, I. Fonta, J. Mosnier, B. Pradines, M.Navarro (2021), “A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent”, ChemMedChem, 16, 662-678


65.  117. D. Moita, H. Nunes-Cabaço, A.M. Mendes, M. Prudêncio (2021) “A guide to investigating immune responses elicited by whole-sporozoite pre-erythrocytic vaccines against malaria”, FEBS J.doi:10.1111/febs.16016


64. T.A. Tavella, N.S.M. Silva, N. Spillman, A.C.A.V.K., G.C. Cassiano, A.A. Vasconcelos, A.P. Camargo, D.C.B. Silva, D. Fontinha, L.C.S. Alvarez, L.T. Ferreira, K.C.P. Tomaz, B.J. Neves, L.D. Almeida, D.Y. Bargieri, M.V.G. Lacerda, P.V.L. Cravo, P. Sunnerhagen, M. Prudêncio, C.H. Andrade, S.C.P. Lopes, M.F. Carazzolle, L. Tilley, E. Bilsland, J.C. Borges, F.T.M. Costa (2021) “Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity” ACS Infect. Dis., 7, 759-776


63. N.G. Alves, I. Bártolo, A.J.S. Alves, D. Fontinha, D. Francisco, S.M.M. Lopes, M.I.L. Soares, C. J.V. Simões, M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2021) “Synthesis and structure-activity relationships of new chiral spiro-b-lactams highly active against HIV-1 and Plasmodium”, Eur. J. Med. Chem., 219, 113439


62. M. Prudêncio (2021) “Portugal’s prominence in malaria research”, EMBO Reports, e51692


61. I Bártolo, B.S. Santos, D. Fontinha, M. Machado, D. Francisco, B. Sepodes, J. Rocha, H. Mota-Filipe, R. Pinto, M.E. Figueira, H. Barroso, T. Nascimento, A.P.A. de Matos, A.J.S. Alves, N.G. Alves, C.J.V. Simões, M. Prudêncio, T.M.V.D. Pinho e Melo, N. Taveira (2021) “Spiro-β-lactam BSS-730A displays potent activity against HIV and Plasmodium”, ACS Infectious Diseases, 7, 2, 421-434


60. M. Fonte, N. Tassi, D. Fontinha, I. Bouzón-Arnáiz, R. Ferraz, M.J. Araújo, X. Fernàndez-Busquets, M. Prudêncio, P. Gomes, C. Teixeira (2020) “4,9-diaminoacridines and 4-aminoacridines as antiplasmodial hits”. ChemMedChem, 16, 799-792


59.  Y. Miyazaki, C.Y. Marin, T. Imai, A.M. Mendes, R. vd Laak, A. Sturm, F.J. Geurten, S. Miyazaki, S.C. Chevalley-Maurel, J. Ramesar, S.K. Kolli, J. Kroeze, R. van Schuijlenburg, A.M. Salman, B.K. Wilder, A. Reyes-Sandoval, K. Dechering, M. Prudêncio, C.J. Janse, S.M. Khan, B. Franke-Fayard (2020) “Generation of a genetically modified chimeric Plasmodium falciparum parasite expressing P. vivax circumsporozoite protein for malaria vaccine development”, Frontiers in Cellular and Infection Microbiology, 10, 591046


58. P. Meireles, D. Brás, D. Fontinha, A.F. Chora, K. Serre, A.M. Mendes*, M. Prudêncio* (2020) “Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation”, iScience, 23, 101781 (*Corresponding authors).  Recommended by Faculty Opinions


57.  M. Marinović, I. Perković, D. Fontinha, M. Prudêncio, J. Held, L. Pessanha de Carvalho, T. Tandarić, R. Vianello, B. Zorc, Z. Rajić (2020) “Novel Harmicines with Improved Potency against Plasmodium”, Molecules, 25, 4376


56. M. Prudêncio (2020) "In fairness to mosquitoes", Trends in Parasitology, 36, 876-877


55.  S.A. Milheiro, J. Gonçalves, R.M.R.M. Lopes, M. Madureira, L. Lobo, A. Lopes, F. Nogueira, D. Fontinha, M. Prudêncio, M.F.M. Piedade, S.N. Pinto, P.R. Florindo, R. Moreira (2020) “Half- sandwich cyclopentadienylruthenium(II) complexes: a new antimalarial chemotype”, Inorganic Chemistry, 59, 12722-12732


54.  D. Fontinha, I. Moules, M. Prudêncio (2020) "Repurposing drugs to fight hepatic malaria parasites", Molecules, 25, 3409


53. M. Prudêncio, J.C. Costa (2020) "Research funding after COVID-19", Nature Microbiol., 5, 986


52. D. Fontinha, S.A. Sousa, T.S. Morais, M. Prudêncio, J.H. Leitão, Y.L. Gal, D. Lorcy, R.A.L. Silva, M.F.G. Velho, D. Belo, M. Almeida, J.F. Guerreiro, T. Pinheiro, F. Marques (2020) "Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents", Metallomics12, 974-987


51.  I.J. Reuling *, A.M. Mendes*, G.M. de Jong GM*, A. Fabra-García*, H. Nunes-Cabaço*, G.J. van Gemert, W. Graumans, L.E. Coffeng, S.J. de Vlas, A.S.P. Yang, C.K. Lee, Y. Wu, A.J. Birkett, C.F. Ockenhouse, R. Koelewijn, J.J. van Hellemond, P.J.J. van Genderen**, R.W. Sauerwein**, M. Prudêncio** (2020) “Safety and efficacy of a genetically modified rodent malaria parasite against Plasmodium falciparum malaria: an open-label randomized phase 1/2a trial”, Science Transl. Med., 12, eaay2578. *Equally contributing authors; **Corresponding authors. Issue cover.


50. L. Singh, D. Fontinha, D. Francisco, A.M. Mendes, M. Prudêncio, K. Singh (2020) “Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites”, J. Med. Chem., 63, 1750-1762


49. R. Azevedo, A.M. Mendes, M. Prudêncio (2020) "The impact of antiretroviral therapy on malaria parasite transmission”, Frontiers in Microbiology-Infectious Diseases, 10, 3048


48. L. Balasubramanian, V. Zuzarte-Luís, T. Syed, D. Mullick, S. Deb, H. Prasad, J. Meissner, A.S. Almeida, T. Furstenhaupt, K. Siddiqi, M. Prudêncio, C.M. Rodrigues, M.M. Mota, V. Sundaramurthy (2020) "Association of Plasmodium berghei with the apical domain of hepatocytes is necessary for the parasite's liver stage development", Frontiers in Cellular Infection Microbiology, 9, 451


47.  I. Perković, S. Raić-Malić, D. Fontinha, M. Prudêncio, L.P. Carvalho, J. Held, T. Tandarić, R. Vianello, B. Zorc, Zrinka Rajić (2020) "Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits", Eur. J. Med. Chem., 187, 111927


46. S.A. Sousa, J.H. Leitão, R.A.L. Silva, D. Belo, I.C. Santos, J.F. Guerreiro, M. Martins, D. FontinhaM. Prudêncio, M. Almeida, D. Lorcy, F. Marques (2020) "On the Path to Gold: Monoanionic Au Bisdithiolate Complexes with 1 Antimicrobial and Antitumor Activities", Journal of Inorganic Biochemistry, 202, 110904


45. A.J.S. Alves, N.G. Alves, C.C. Caratão, Esteves M., D. Fontinha, I. Bártolo, M.I.L. Soares, S.M.M. Lopes, M. Prudêncio, N. Taveira, T.M.V.D. Pinho e Melo (2019) "Spiro-Lactams as Novel Antimicrobial Agents", Curr. Top. Med. Chem., 20, 140-152


44. M. Sanches-Vaz, A. Temporão, R. Luis, H. Nunes-Cabaço, A.M. Mendes, S. Goellner, T. Carvalho, L.M. Figueiredo*, M. Prudêncio* (2019) "Trypanosoma brucei infection protects mice against malaria", PLoS Pathogens, 15, e1008145 (* Corresponding authors)


43. R. Azevedo, A.M. Mendes, M.Prudêncio (2019) "Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins", Parasites & Vectors, 12, 594


42. F. Arez, S. Rebelo, D. Fontinha, D. Simão, T.R. Martins, M. Machado, C. Fischli, C. Oeuvray, L. Badolo, M. J. T. Carrondo, M. Rottmann, T. Spangenberg, C. Brito, B. Greco*, M. Prudêncio*, P.M. Alves* (2019) “Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection”, ACS Infect. Dis., 5, 1831-1842 (* Corresponding authors)


41.  K. Pavić, B. Rubinić, Z. Rajić, D. Fontinha, M. Prudêncio, L. Uzelac, M. Kralj, J. Held, B. Zorc (2019) “Primaquine homodimers as potential antiplasmodial and anticancer agents”, Bioorganic & Medicinal Chemistry Letters, 29, 126614

40. K. Wolanin, D. Fontinha, M. Sanches‐Vaz, B. Nyboer, Kirsten Heiss, A.-K. Mueller, M. Prudêncio (2019) “A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle”, Cell. Microbiol., e13088

39. M. Beus, D. Fontinha, J. Held, Z. Rajić, L. Uzelac, M. Kralj, M. Prudêncio, B. Zorc (2019) "Primaquine and chloroquine fumardiamides as promising antiplasmodial agents”, Molecules, 24, 2812

38. M. Beus*, D. Fontinha*, J. Held, Z. Rajić, M. Prudêncio, B. Zorc (2019) "Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides", Acta Pharmaceutica, 69, 233-248 (* Equally contributing authors)

37. L. Aguiar, M. Machado, M. Sanches-Vaz, M. Prudêncio, N. Vale, Paula Gomes (2019) “Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites”, MedChemComm, 10, 221-226

36. G. Mayoka, M. Njoroge, J. Okombo, L. Gibhard, M. Sanches-Vaz, D. Fontinha, L.M. Birkholtz, J. Reader, M. van der Watt, T.L. Coetzer, S. Lauterbach, A. Churchyard, B. Bezuidenhout, T.J. Egan, C.L. Yeates, S. Wittlin, M. Prudêncio, K. Chibale (2019) “Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria”, J. Med. Chem., 62, 1022-1035


35. M. Kumar, J. Okombo, D. Mambwe, D. Taylor, N. Lawrence, J. Reader, M.V. Watt, D. Fontinha, M. Sanches-Vaz, B. Bezuidenhout, S. Lauterbach, D. Liebenberg, L.M. Birkholtz, T.L. Coetzer, M. Prudêncio, T.J. Egan, S. Wittlin, K. Chibale (2019) “Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action”, ACS Infect. Dis., 5, 303-315


34. A.M. Mendes, I.J. Reuling, C.M. Andrade, T.D. Otto, M. Machado, F. Teixeira, J. Pissarra, N. Gonçalves-Rosa, D. Bonaparte, J. Sinfrónio, M. Sanders, C.J. Janse, S.M. Khan, C.I. Newbold, M. Berriman, C. Lee, Y. Wu, C.F. Ockenhouse, R.W. Sauerwein, M. Prudêncio (2018) "Pre-Clinical Evaluation of a P. berghei-Based Whole-Sporozoite Malaria Vaccine Candidate", NPJ Vaccines, 3, 54

33. M. Beus, Z.R. Džolić, D. Maysinger, Z. Mlinarić, M. Antunović, I. Marijanović, D. Fontinha, M. Prudêncio, J. Held, S. Olgen, B. Zorc (2018) "SAHAquines, novel hybrids based on SAHA and primaquine motifs, as potential cytostatic and antiplasmodial agents", ChemistryOpen, 7, 624-638

32. A.M. Mendes, M. Machado, N. Gonçalves-Rosa, I.J. Reuling, L. Foquet, C. Marques, A.M. Salman, A.S.P. Yang, K.A. Moser, A. Dwivedi, C.C. Hermsen, B. Jiménez-Díaz, S. Viera, J.M. Santos, I. Albuquerque, S.N. Bhatia, J. Bial, I. Angulo-Barturen, J.C. Silva, G. Leroux-Roels, C.J. Janse, S.M. Khan, M.M. Mota, R.W. Sauerwein, M. Prudêncio (2018) "A Plasmodium berghei Sporozoite-Based Vaccination Platform Against Human Malaria", NPJ Vaccines, 3, 33

31. R. Capela, J. Magalhães, D. Miranda, M. Machado, M. Sanches-Vaz, I.S. Albuquerque, M. Sharma, J. Gut, P.J. Rosenthal, R. Frade, M.J. Perry, R. Moreira, M. Prudêncio*, F. Lopes* (2018) "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability", Eur. J. Med. Chem., 149, 69-78. *- Corresponding authors

30. M. Šafratová, A. Hošťálková, D. Hulcová, K. Breiterová, V. Hrabcová, M. Machado, D. Fontinha, M. Prudêncio, J. Kuneš, J. Chlebek, D. Jun, M. Hrabinová, L. Nováková, R. Havelek, M. Seifrtová, L. Opletal, L. Cahlíková (2018) "Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity", Arch. Pharmacal Res., 41, 208-218

29. K. Pavic, I. Perkovic, S. Popisilova, M. Machado, D. Fontinha, M. Prudêncio, J. Jampilek, A. Coffey, L. Endersen, H. Rimac, B. Zorc (2017) "Primaquine hybrids as promising antimycobacterial and antimalarial agents", Eur. J. Med. Chem., 143, 769-779

28. T.S. Macedo, W. Villarreal, C.C. Couto, D.R.M. Moreira, M. Navarro, M. Machado, M. Prudêncio, A.A. Batista, M.B.P. Soares (2017) "Platinum(II)-chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function", Metallomics, 9, 1548-1561

27. M. Machado, M. Sanches-Vaz, J.P. Cruz, A.M. Mendes, M. Prudêncio (2017) "Inhibition of Plasmodium hepatic infection by antiretroviral compounds", Front. Cell. Infect. Microbiol., 7, doi: 10.3389/fcimb.2017.00329

26. P. Meireles, A.M. Mendes, R.I. Aroeira, B.C. Mounce, M. Vignuzzi, H.M. Staines, M. Prudêncio (2017) "Uptake and metabolism of arginine impact Plasmodium development in the liver", Sci. Rep., 7, 4072

25. R. Azevedo§, M. Markovic§, M. Machado, B. Franke-Fayard, A.M. Mendes*, M. Prudêncio* (2017) "A bioluminescence method for in vitro screening of Plasmodium transmission-blocking compounds", Antimicrob. Agents Chemother., 61, 202699-16. §- Equally contributing authors; *- Corresponding authors

24. K. Singh, J. Okombo, C. Brunschwig, F. Ndubi, L. Barnard, C. Wilkinson, P.M. Njogu, M. Njoroge, L. Laing, M. Machado, M. Prudêncio, J. Reader, M. Botha, S. Nondaba, L.M. Birkholtz, S. Lauterbach, A. Churchyard, T.L. Coetzer, J.N. Burrows, C. Yeates, P. Denti, L. Wiesner, T.J. Egan, S. Wittlin, K. Chibale (2017) "Antimalarial pyrido[1,2-a]benzimidazoles: Lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics and in vivo oral efficacy in a mouse model", J. Med. Chem., 60, 1432-1448

23. C.S. Cunha§, B. Nyboer§, K. Heiss, M. Sanches-Vaz, D. Fontinha, E. Wiedtke, D. Grimm, J.M. Przyborski, M.M. Mota, M. Prudêncio*, A.K. Mueller* (2017) "P. berghei EXP-1 Interacts with Host Apolipoprotein H during Plasmodium Liver Stage Development", Proc. Natl. Acad. Sci. USA, 114, E1138-E1147. §- Equally contributing authors; *- Corresponding authors

22. A.M. Mendes, I.S. Albuquerque, M. Machado, J. Pissarra, P. Meireles, M. Prudêncio (2017) "Inhibition of Plasmodium liver infection by ivermectin", Antimicrob. Agents Chemother., 61, e02005-16

21. M.A.S. Cavadas, M.P. Monopoli, C.S. Cunha, M. Prudêncio, E. Pereira, I. Lynch, K.A. Dawson, R. Franco (2016) "Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates", Particle & Particle Systems Characterization, 33, 906-915

20. Carrasco M.P.*, Machado M., Gonçalves L., Sharma M., Gut J., Lukens A.K., Wirth D.F., André V., Duarte M.T., Guedes R.C., Dos Santos D., Rosenthal P.J., Mazitschek R., Prudêncio M.*, Moreira R. (2016) "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites", ChemMedChem, 11, 2194-2204  (* Corresponding authors)

19. P. Meireles, J. Sales-Dias, C.M. Andrade, J. Mello-Vieira, L. Mancio-Silva, J.P. Simas, H.M. Staines, M. Prudêncio (2016) "GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection", Cell. Microbiol., doi:10.1111/cmi.12646

18. R. Ferraz, J. Noronha, F. Murtinheira, F. Nogueira, M. Machado, M. PrudêncioB., S. Parapini, S. D’Alessandro, C. Teixeira, A. Gomes, C. Prudêncio, P. Gomes (2016) "Primaquine-based ionic liquids as a novel class of antimalarial hits", RSC Advances, 6, 56134-56138

17. T.S. Macedo, L.C. Vegas, M. Paixão, M. Navarro, B.C. Barreto, P.C.M..Oliveira, S.G. Macambira, M. Machado, M. Prudêncio, S. D’Alessandro, N. Basilico, D.R.M. Moreira, A.A. Batista, M.B.P. Soares (2016) "Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents", Parasitology, 143, 1543-1556

16. C.J.A. Ribeiro, M. Espadinha, M. Machado, J. Gut, L.M. Gonçalves, P.J. Rosenthal, M. Prudêncio, R. Moreira, M.M.M. Santos (2016) "Novel squaramides with in vitro liver stage antiplasmodial activity", Bioorg. Med. Chem., 24, 1786-1792

15. N. Terzić, J. Konstantinović, M. Tot, J. Burojević, O. Djurković-Djaković, J. Srbljanović, T. Štajner, T. Verbić, M. Zlatović, M. Machado, I.S. Albuquerque, M. Prudêncio*, R.J. Sciotti, S. Pecic, S. D’Alessandro, D. Taramelli, B.A. Šolaja* (2016) "Re-investigating old pharmacophores: Are 4-aminoquinolines and tetraoxanes potential two-stage antimalarials?", J. Med. Chem., 59, 264-281 (* Corresponding authors)

14. I. Gomes, A. Reis, E. Pereira, E. Fortunato, M. Prudêncio, R. Franco (2015) "Nanoimunoensaios para diagnóstico de malária", An. Inst. Hig. Med. Trop., 14, 21-30

13. N.A.L. Pereira, Â. Monteiro, M. Machado, J. Gut, E. Molins, M.J. Perry, J. Dourado, R. Moreira, P.J. Rosenthal, M. Prudêncio*, and M.M.M. Santos* (2015), "Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites". ChemMedChem, 10, 2080-2089 (* Corresponding authors)

12. A. Gomes, M. Machado, L. Lobo, F. Nogueira, M. Prudêncio, C. Teixeira, P. Gomes (2015) "N-cinnamoylation of antimalarial classics: Effects of using acyl groups other than cinnamoyl toward dual-stage antimalarials", ChemMedChem, 10, 1344-134

11. H. Kaur, M. Machado, C. de Kock, P. Smith, K Chibale, M Prudêncio, K. Singh (2015) "Primaquineepyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity", European Journal of Medicinal Chemistry, 101, 266-273

10. M.D. Lewis, J. Behrends, C.S. Cunha, A.M. Mendes, F. Lasitschka, K. Heiss, T.W.A. Kooij, M.Prudêncio, F.Frischknecht and A.-K. Mueller (2015), "Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression", Journal of Immunology, 194, 4860-4870

9. C.A.B. Rodrigues, R.F.M. Frade, I.S. Albuquerque, M.J. Perry, J. Gut, M. Machado, P.J. Rosenthal, M. Prudêncio, C.A.M. Afonso, R. Moreira (2015), "Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids", ChemMedChem, 10, 883-890

8. P. Liehl*, P. Meireles*, I.S. Albuquerque, M. Pinkevych, F. Baptista, M.M. Mota, M.P. Davenport, M. Prudêncio (2015), "Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections", Infection and Immunity, 83, 1172-1180. (* Equally contributing authors)

7. C. Ramalhete, F.P. da Cruz, I.J. Sousa, S. Mulhovo, M.X. Fernandes, M. Prudêncio, M.-J.U. Ferreira (2014), "Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite", Bioorganic & Medicinal Chemistry, 22, 3887-3890

6. R. Oliveira, R.C. Guedes, P. Meireles, I.S. Albuquerque, L.M. Gonçalves, E. Pires, M.R. Bronze, J. Gut, P.J. Rosenthal, M. Prudêncio, R. Moreira, P.M. O’Neill, F. Lopes (2014), "Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials", J. Med. Chem., 57, 4916-4923

5. D. Miranda, R. Capela, I.S. Albuquerque, P. Meireles, I. Paiva, F. Nogueira, R. Amewu, J. Gut, P.J. Rosenthal, R. Oliveira, M.M. Mota, R. Moreira, F. Marti, M. Prudêncio, P.M. O’Neill, F. Lopes (2014) "Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities", ACS Medicinal Chemistry Letters, 5, 108-112

4. A. Gomes, B. Pérez, I. Albuquerque, M. Machado, M. Prudêncio, F. Nogueira, C. Teixeira, P. Gomes (2014) "N-cinnamoylation of antimalarial classics: new quinacrine analogues with reduced toxicity and dual-stage activity", ChemMedChem, 9, 305-310

3. P. Liehl, V. Zuzarte-Luís, J. Chan, T. Zillinger, F. Baptista, D.l Carapau, M. Konert, K. Hanson, C. Carret, C. Lassnig, M. Müller, U. Kalinke, M. Saeed, A.F. Chora, D.T. Golenbock, B. Strobl, M. Prudêncio, L.P. Coelho, S.H. Kappe, G. Superti-Furga, A. Pichlmair, A.M. Vigário, C.M. Rice, K.A. Fitzgerald, W. Barchet, M.M. Mota (2014) "Host cell sensors for Plasmodium activate innate immunity against liver stage infection", Nature Medicine, 20, 47-53

2.  A.S. Ressurreição, D. Gonçalves, A.R. Sitoe, I.S. Albuquerque, J. Gut, A. Góis, L.M. Gonçalves, M.R. Bronze, T. Hanscheid, G.A. Biagini, P.J. Rosenthal, M. Prudêncio, P. O'Neill, M.M. Mota, F. Lopes, R. Moreira (2013) "Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: towards increased potency and metabolic stability", J. Med. Chem, 56, 7679-7960

1. T. Rodrigues, A.S. Ressurreição, F.P. da Cruz, I.S. Albuquerque, J. Gut, M. Carrasco, D. Gonçalves, M.M. Mota, P.J. Rosenthal, R. Moreira, M. Prudêncio, F. Lopes (2013) "Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds", Eur. J. Med. Chem., 69, 872-880
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