Publications by Miguel Prudêncio (up to July 2013)

52. K. Hanson, A.S. Ressurreição, K. Buchholz, M. Prudêncio, J. Herman, M. Rebelo, W. Beatty, D. Wyrth, T. Hanscheid, R. Moreira, M. Marti, M.M. Mota (2013) "Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins", Proc. Natl. Acad. Sci. USA, 110, E2838-E2847

51. T. Rodrigues, F.P. da Cruz, M. Lafuente-Monasterio, D. Gonçalves, A. Ressurreição, A.R. Sitoe, M.R. Bronze, J.Gut, G. Schneider, M.M. Mota, P.J. Rosenthal, M. Prudêncio, F.-J. Gamo, F. Lopes, R. Moreira (2013) "Quinolon-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria", J. Med. Chem., 56, 4811-4815

50. E. Dempsey, M. Prudêncio, B.J. Fennell, C.S. Gomes-Santos, J.W. Barlow, A. Bell (2013) "Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites", Mol. Biochem. Parasitol., 188, 116-127. Highlighted as Feature Article on Malaria Nexus

49. J. Lin, P. Meireles, M. Prudêncio, S. Engelmann, T. Annoura, M. Sajid, S. Chevalley‐Maurel, J. Ramesar, C. Nahar, C.M.C. Avramut, A.J. Koster, K. Matuschewski, A.P. Waters, C.J. Janse, G.R. Mair, S.M. Khan (2013) "Loss‐of‐Function Analyses Defines Vital and Redundant Functions of the Plasmodium Rhomboid Protease Family", Mol. Microbiol., 88, 318-338

48. B.C. Pérez, C. Teixeira, I.S. Albuquerque, J. Gut, P.J. Rosenthal, J.R.B. Gomes, M. Prudêncio, P. Gomes (2013) "N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads", J. Med. Chem., 56, 556-567

47. M. Prudêncio*, Maria M. Mota* (2013) "Targeting host factors to circumvent anti-malarial drug resistance", Curr. Pharm. Des., 19, 290-299 (Review) (* Corresponding authors)

46. B.C. Pérez, C. Teixeira, A.S. Gomes, I.S. Albuquerque, J. Gut, P.J. Rosenthal, M. Prudêncio, P. Gomes (2013) "In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites", Bioorganic & Medicinal Chemistry Letters,  23, 610-613 

45. B.C. Pérez, C. Teixeira, I.S. Albuquerque, J. Gut, P.J. Rosenthal, M. Prudêncio* , P. Gomes* (2012) "PRIMACINS, N-cinnamoyl-primaquine conjugates with improved liver-stage antimalarial activity", Med. Chem. Commun., 3, 1170-1172 (* Corresponding authors) 

44. E.R. Derbyshire, M. Prudêncio, M.M. Mota, J. Clardy (2012) "Liver stage malaria parasites vulnerable to diverse chemical scaffolds", Proc. Natl. Acad Sci. USA, 109, 8511-8516

43. F.P. da Cruz, C. Martin, K. Buchholz K, M.J. Lafuente-Monasterio, T. Rodrigues, B. Sönnichsen, R. Moreira, F.J. Gamo, M. Marti, M.M. Mota, M. Hannus, M. Prudêncio* (2012) “Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multi-Stage Anti-Malarial Drug”, J. Inf. Dis., 205, 1278-1286, Evaluated by Faculty of 1000 Biology and Medicine  (* Corresponding author)

42. B.S.S. Guirgis, C.S. Cunha, I. Gomes, M. Cavadas, I. Silva, G. Doria, G.L. Blatch, P.V. Baptista, E. Pereira, H.M.E. Azzazy, M.M. Mota, M. Prudêncio, R. Franco (2012) ”Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection”, Anal. Bioanal. Chem., 402, 1019-1027

41. J. Matos, F.P. da Cruz, E. Cabrita, J. Gut, F. Nogueira, V.E. do Rosário, R. Moreira, P.J. Rosenthal , M. Prudêncio, P. Gomes (2012) “Novel potent metallocenes against liver stage malaria”, Antimicrob. Agents Chemother., 56, 1564-1570

40. T. Rodrigues, M. Prudêncio, R. Moreira, M.M. Mota, F. Lopes (2012) “Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal”, J. Med. Chem., 55, 995-1012

39. P. Eaton, V. Zuzarte-Luis, M.M. Mota, N.C. Santos, M. Prudêncio (2012) “Infection by Plasmodium changes shape and stiffness of hepatic cells”, Nanomedicine, 8, 17-19

38. C. Almeida, S. Kehraus, M. Prudêncio, G.M. König (2011) “Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp”, Beilstein J. Org. Chem., 7, 1636–1642

37. C. Ramalhete, F.P. da Cruz, D. Lopes, S. Mulhovo, V.E. Rosário, M. Prudêncio, M.J.U. Ferreira (2011) “Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections”, Bioorg. Med. Chem., 19, 7474-7481

36. M. Prudêncio*, M.M. Mota, A.M. Mendes (2011) “A toolbox to study liver stage malaria”, Trends Parasitol., 27, 565-574 (Review), Selected by MalariaNexus  (* Corresponding author)

35. R. Capela, G.G. Cabal, P.J. Rosenthal, J. Gut, M.M. Mota, R. Moreira, F. Lopes, M. Prudêncio* (2011) “Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy”, Antimicrob. Agents Chemother., 55, 4698-4706  (* Corresponding author)

34. C.S.S. Gomes-Santos§, J. Braks§, M. Prudêncio , C. Carret, A.R. Gomes, A. Pain, T. Feltwell, S. Khan, A. Waters, C. Janse, G.R. Mair, M.M. Mota (2011) “Transition of Plasmodium Sporozoites into Liver Stage-Like Forms Is Regulated by the RNA Binding Protein Pumilio”, PloS Pathogens, 7(5):e1002046 (§ Equally contributing authors)

33. J. Lavrado, G.G. Cabal, M. Prudêncio, M.M. Mota, J. Gut, P.J. Rosenthal, C. Díaz, R.C. Guedes, D.J. Dos Santos, E. Bichenkova, K.T. Douglas, R. Moreira, A. Paulo (2011) “Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies”, J. Med. Chem., 54, 734-750

32. K. Slavic, M.J. Delves, M. Prudêncio, A.M. Talman, U. Straschil, E.T. Derbyshire, Z. Xu, R.E. Sinden, M.M. Mota, C. Morin, R. Tewari, S. Krishna, H.M. Staines (2011) “Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle”, Antimicrob. Agents Chemother., 55, 2824-2830

31. P. Liehl, A.R. França, M. Prudêncio, E. Latz, A. Zaidman-Rémy, M.M. Mota (2010) “Phosphothioate Oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility”, Cell. Microbiol., 12, 506-515

30. I.H. Ploemen§, M. Prudêncio§, B.G. Douradinha, J. Ramesar, J. Fonager, G.J. van Gemert, A.J. Luty, C.C. Hermsen, R.W. Sauerwein, F.G. Baptista, M.M. Mota, A.P. Waters, I. Que, C.W. Lowik, S.M. Khan, C.J Janse, B.M. Franke-Fayard (2009) “Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging”, PLoS ONE, 4, e7881 (§ Equally contributing authors)

29. N. Vale, M. Prudêncio, C.A. Marques, M.S. Collins, J. Gut, F. Nogueira, J. Matos, P.J. Rosenthal, M.T. Cushion, V.E. do Rosário, M.M. Mota, R. Moreira, P. Gomes (2009) “Imidazoquines as Antimalarial and Antipneumocystis Agents”, J. Med. Chem., 52, 7800-7807

28. M. Prudêncio§, E.T. Derbyshire§, C.A. Marques, S. Krishna, M.M. Mota, H.M. Staines (2009) “Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells”, Cell. Microbiol., 11, 1492-1501 (§ Equally contributing authors)

27. S.S. Albuquerque, C. Carret, A.R. Grosso, A.S. Tarun, X. Peng, S.H.I. Kappe, M. Prudêncio, M.M. Mota (2009) “Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events”, BMC Genomics, 10, 270-282

26. M. Prudêncio, M.J. Lehmann (2009) “Illuminating the host - How RNAi screens shed light on host-pathogen interactions”, Biotechnol. J., 4, 826-837

25. I. Parvanova, S. Epiphanio, A. Fauq, T.E. Golde, M. Prudêncio, M.M. Mota (2009) “A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity”, PLoS ONE, 4, e5078

24. M. Prudêncio§, C.D. Rodrigues§, M. Hannus, C. Martin, E. Real, L .A. Gonçalves, C. Carret, R. Dorkin, I. Röhl, K. Jahn-Hoffmann, A.J.F. Luty, R. Sauerwein, C.J. Echeverri, M.M. Mota (2008) “Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection”, PloS Pathogens, 4, 1-15 (§ Equally contributing authors)

23. M.G. Finiguerra, , M. Ubbink, M. Huber (2008) “Accurate Long-Range Distance Measurements in a Doubly Spin-Labeled Protein by a Four-Pulse, Double Electron-Electron Resonance Method”, Magn. Reson. Chem., 46, 1096-1101

22. C.D. Rodrigues§, M. Hannus§, M. Prudêncio§, C. Martin, L.A. Gonçalves, S. Portugal, S. Epiphanio, A. Akinc, P. Hadwiger, K. Jahn-Hofmann, I. Röhl, G.J. van Gemert, J.F. Franetich, A.J. Luty, R. Sauerwein, D. Mazier, V. Koteliansky, H.P. Vornlocher, C.J. Echeverri, M.M. Mota (2008) “Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection”, Cell Host & Microbe, 11, 4, 271-282, ) § Equally contributing authors)

21. O. Silvie, M.M. Mota, K. Matuschewski,  M. Prudêncio (2008) “Interactions of the malaria parasite and its mammalian host”, Curr. Opin. Microbiol., 11, 352-359 (Review)

20. M. Cunha-Rodrigues§, S. Portugal§, M. Prudêncio, L.A. Gonçalves, C. Casalou, D. Buger, R. Sauerwein, W. Haas, M.M. Mota (2008) “Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy”, PLoS ONE, 3, e2732 (§ Equally contributing authors)

19. M.D. Vlasie, R. Fernández-Busnadiego, M. Prudêncio, M. Ubbink (2008) “Conformation of Pseudoazurin in the 152 kDa Electron Transfer Complex with Nitrite Reductase Determined by Paramagnetic NMR”*; J. Mol. Biol., 375, 1405-1415 (*Issue cover)

18. M. Prudêncio*, C.D. Rodrigues, R. Ataíde, M.M. Mota* (2008), “Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry”, Cell. Microbiol., 10, 218-224 (* Corresponding authors)

17. M. Prudêncio, M.M. Mota (2007), “To migrate or to invade: those are the options”, Cell Host & Microbe, 2, 286-288 (Review)

16. M. D. Vlasie, C. Comuzzi, A. M. C. H. van den Nieuwendijk, M. Prudêncio, M. Overhand, M. Ubbink (2007), “Long-range-distance NMR effects in a protein labeled with a lanthanide–DOTA chelate”, Chem. Eur. J., 13, 1715 – 1723

15. T.E. de Jongh, A.-M. van Roon, M. Prudêncio, M. Ubbink, G.W. Canters (2006), “Click chemistry with an active site variant of azurin”, Eur. J. Inorg. Chem., 3861-3868

14. M. Prudêncio, A. Rodriguez, M.M. Mota (2006), “The silent path to thousands of merozoites: the Plasmodium liver stage”, Nat. Rev. Microbiol., 2006, 4, 849-856 (Review)

13. M. Cunha-Rodrigues, M. Prudêncio, M.M. Mota, W. Haas (2006) “Antimalarial drugs - host targets (re)visited”, Biotechnol. J., 1, 321-332 (Review)

12. J.A. Worrall, R.E. Diederix, M. Prudêncio, C.E. Lowe, S. Ciofi-Baffoni, M. Ubbink, G.W. Canters (2005) “The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding”, ChemBioChem, 6, 747-758

11. R.L. Harris, M. Prudêncio, S.S. Hasnain, R.R. Eady and G. Sawers (2005) “Heterologous metalloprotein biosynthesis in Escherichia coli: conditions for the overproduction of functional copper-containing nitrite reductase and azurin from Alcaligenes xylosoxidans”, J. Synchrotron Rad., 12, 13–18

10. M. Prudêncio, M. Ubbink (2004) “Transient Complexes of Redox Proteins: Structural and Dynamic Details from NMR Studies”, J. Mol. Recognit., 17, 524-539 (Review)

9. M. Prudêncio, J. Rohovec, J.A. Peters, E. Tocheva, M.J. Boulanger, M.E.P. Murphy, H.-J. Hupkes, W. Kosters, A. Impagliazzo, M. Ubbink (2004) “A Caged Lanthanide Complex as a Paramagnetic Shift Agent for Protein NMR”, Chem. Eur. J., 10, 3252-3260

8. O. Farver, R.R. Eady, G. Sawers, M. Prudêncio, I. Pecht (2004) “Met144Ala Mutation of the Copper-Containing Nitrite Reductase from Alcaligenes xylosoxidans reverses the Intramolecular Electron Transfer”, FEBS Lett., 561, 173-176

7. M. Prudêncio, G. Sawers, S.A. Fairhurst, F.K. Yousafzai, R.R. Eady (2002) “Alcaligenes xylosoxidans Dissimilatory Nitrite Reductase: Alanine Substitution of the Surface-exposed Histidine 139 Ligand of the Type 1 Copper Center Prevents Electron Transfer to the Catalytic Center”, Biochemistry, 41, 3430-3438

6. M.J. Ellis, M. Prudêncio, F.E. Dodd, R.W. Strange, G. Sawers, R.R. Eady, S.S. Hasnain (2002) “Biochemical and Crystallographic Studies of the Met144Ala, Asp92Asn and His254Phe Mutants of the Nitrite Reductase from Alcaligenes xylosoxidans Provide Insight into the Enzyme Mechanism”, J. Mol. Biol., 316, 51-64

5. M.J. Ellis, F.E. Dodd, R.W. Strange, M. Prudêncio, G. Sawers, R.R. Eady, S.S. Hasnain (2001) “X-ray Structure of a Blue Copper Nitrite Reductase at High pH and in Copper-free Form at 1.9 Angstrom Resolution”, Acta Crystallogr. D, 57, 1110-1118

4. M. Prudêncio, R.R. Eady, G. Sawers (2001) “Catalytic and Spectroscopic Analysis of Blue Copper-containing Nitrite Reductase Mutants Altered in the Environment of the Type 2 Copper Centre: Implications for Substrate Interaction”, Biochem. J., 353, 259-266

3. M. Prudêncio, A.S. Pereira, P. Tavares, S. Besson, I. Cabrito, K. Brown, B. Samyn, B. Devreese, J. Van Beeumen, F. Rusnak, G. Fauque, J. J. G. Moura, M. Tegoni, C. Cambillau and I. Moura (2000) “Purification, Characterization and Preliminary Crystallographic Study of Copper-Containing Nitrous Oxide Reductase from Pseudomonas nautica 617”, Biochemistry, 39, 3899-3907

2. K. Brown, M. Tegoni, M. Prudêncio, A.S. Pereira, S. Besson, J. J. G. Moura, I. Moura and C. Cambillau (2000) “A Novel Type of Catalytic Copper Cluster in Nitrous Oxide Reductase”, Nature Struct. Biol., 7, 191-195

1. M. Prudêncio, R. R. Eady, and G. Sawers (1999) “The Blue Copper-containing Nitrite Reductase from Alcaligenes xylosoxidans: Cloning of the nirA gene and Characterisation of the Recombinant Enzyme”, J. Bact., 181, 2323-2329